Opportunity Information: Apply for RFA CE 25 149
The Centers for Disease Control and Prevention (CDC) is offering a discretionary cooperative agreement opportunity titled "Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose" (Funding Opportunity Number RFA CE 25 149; CFDA 93.136). The core purpose is to fund research that produces strong, credible evidence about what works to prevent overdoses and substance use harms, specifically for groups and communities carrying a disproportionate burden of overdose. The announcement emphasizes populations with higher risk of exposure to drug use or worse outcomes linked to social determinants of health, meaning applicants should be prepared to clearly define inequities, explain why the target population is disproportionately affected, and design an evaluation that can speak to reducing those inequities.
Funded projects are expected to rigorously evaluate prevention strategies that are either primary prevention (aimed at stopping drug use or misuse and related harms before they start) or secondary prevention (aimed at early identification and intervention to prevent escalation, recurrence, or overdose among those already at risk). The outcomes of interest include reductions in nonfatal overdose, fatal overdose, and/or substance use disorders, including those involving federally illegal drugs and the misuse of prescription medications. The opportunity also highlights the importance of evaluating strategies that reduce drug use or initiation of drug use, with a particular emphasis on youth, so projects that can credibly measure youth initiation, exposure, and protective factors are well aligned.
This is a cooperative agreement rather than a standard grant, which typically means CDC expects substantial involvement during the project period (for example, in aligning evaluation methods, supporting dissemination, or coordinating with broader CDC priorities). The NOFO is geared toward evaluation quality, so competitive applications will generally need a clear theory of change, well-specified comparison or counterfactual approach where feasible, robust outcome measurement (such as linked surveillance, clinical, EMS, claims, medical examiner, or other high-quality data sources), and analytic methods that can credibly attribute changes in overdose outcomes to the intervention rather than to background trends. While the NOFO language does not list specific allowable interventions in the excerpt provided, it is explicit that the focus is not simply implementing programs, but generating rigorous evidence about prevention approaches serving disproportionately affected populations.
Eligibility is broad and includes state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized tribal governments and other tribal organizations; public and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than IHEs); for-profit organizations (other than small businesses) and small businesses; and other unrestricted applicants. The CDC specifically encourages applications from higher education institutions, including Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions, as well as nonprofits, faith-based or community-based organizations, and regional organizations. The NOFO also allows "bona fide agents" applying on behalf of a state or local government, but those applicants must provide a legal, binding agreement documenting that status as part of the application attachments. Federally Funded Research and Development Centers (FFRDCs) are also eligible.
Key logistics include an original application closing date of 2024-12-02, an award ceiling of $700,000, and an expected total of 7 awards. In practical terms, this suggests a competitive, multi-award research portfolio where CDC is looking for a set of rigorous evaluations across different settings and populations, with each award sized to support a serious evaluation effort rather than small pilot work. Applicants should plan to demonstrate both access to the target population and intervention setting (such as schools, healthcare systems, community organizations, harm reduction programs, justice settings, or housing contexts) and the data and evaluation capacity needed to measure overdose and related outcomes reliably over time.Apply for RFA CE 25 149
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Rigorous Evaluation of Primary and Secondary Overdose Prevention Activities Among Populations Disproportionately Affected by Overdose" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on 2024-08-30.
- Applicants must submit their applications by 2024-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others, Unrestricted.
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