Opportunity Information: Apply for PAR 22 141
The National Eye Institute (NEI), part of the National Institutes of Health (NIH), is offering a discretionary research grant opportunity titled "NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)" under Funding Opportunity Number PAR-22-141 (CFDA 93.867). This program uses the NIH R21 mechanism, which is designed for exploratory or developmental work, and it specifically supports vision-related studies that rely on analyzing data that already exist rather than collecting new primary data through a clinical trial. As stated in the announcement, clinical trials are not allowed under this FOA, so proposed projects should focus on secondary analyses of established datasets or databases and should not involve prospective assignment of human participants to interventions.
The central purpose of the FOA is to fund high-quality, meritorious research that advances knowledge about vision, eye health, visual function, or vision-related conditions by leveraging existing database resources. In practical terms, this can include reanalyzing large cohort datasets, registries, administrative claims, electronic health record-derived datasets, public health surveillance data, imaging repositories, genomic or multi-omics repositories, or other curated research databases where the data have already been collected. The program also allows applicants to propose the development of statistical methods or analytic approaches that improve how vision health data are analyzed, as long as the work is grounded in and demonstrated using existing vision-related data resources. This makes the FOA relevant both to substantive vision science questions (for example, risk factors, disease progression, disparities, outcomes, and real-world patterns of care) and to methodological innovation (for example, better modeling, harmonization, bias adjustment, missing data strategies, or validation approaches tailored to vision datasets).
Eligible applicants span a broad range of organizations. Standard eligible entities include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (excluding higher education institutions, which are listed separately); for-profit organizations other than small businesses; small businesses; and other eligible organizations. The FOA also explicitly welcomes a wide set of additional applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This broad eligibility is intended to encourage participation from diverse institutional types and communities, including organizations that may bring unique datasets, expertise, or perspectives on vision health and disparities.
From an administrative standpoint, the opportunity is categorized as a grant in the health funding activity area. The announcement record lists an award ceiling of $275,000. The original closing date shown is May 7, 2025, and the opportunity was created on March 15, 2022. Applicants considering this FOA should plan proposals around feasible, well-justified analyses that can be completed within an R21-style scope, clearly identify the existing data source(s) to be used, explain the analytic plan and statistical rigor, and demonstrate how the work will produce meaningful advances in vision research without initiating a clinical trial or collecting intervention-based prospective outcomes.Apply for PAR 22 141
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.867.
- This funding opportunity was created on 2022-03-15.
- Applicants must submit their applications by 2025-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "NEI Research Grant for Vision-Related Secondary Data Analysis (R21 Clinical Trial Not Allowed)."
Which agency is offering this grant?
The grant is offered by the National Eye Institute (NEI), which is part of the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-22-141.
What CFDA number is associated with this opportunity?
The announcement lists CFDA 93.867.
What type of grant mechanism does this program use?
This program uses the NIH R21 mechanism, which is intended for exploratory or developmental research projects.
What is the main purpose of this FOA?
The central purpose is to support high-quality, meritorious research that advances knowledge about vision, eye health, visual function, or vision-related conditions by using and analyzing data that already exist.
Does this FOA allow clinical trials?
No. Clinical trials are not allowed under this FOA. Projects should not involve prospective assignment of human participants to interventions.
What kind of research is this FOA designed to support?
It supports vision-related secondary data analysis, meaning studies that leverage established datasets or databases instead of collecting new primary data through a clinical trial.
What does "secondary data analysis" mean in the context of this FOA?
In this context, it means analyzing data that have already been collected and curated in existing datasets or database resources, rather than generating new intervention-based, prospectively collected outcomes from a clinical trial.
What types of existing data sources can be used?
The FOA description includes examples such as large cohort datasets, registries, administrative claims, electronic health record-derived datasets, public health surveillance data, imaging repositories, genomic or multi-omics repositories, and other curated research databases where data have already been collected.
Is the FOA limited to specific scientific topics within vision research?
The FOA broadly targets research that advances knowledge in vision, eye health, visual function, and vision-related conditions, and it emphasizes using existing database resources to do so.
Are methodological or statistical methods projects allowed?
Yes. Applicants may propose the development of statistical methods or analytic approaches that improve how vision health data are analyzed, as long as the work is grounded in and demonstrated using existing vision-related data resources.
What are examples of methodological innovations that fit this FOA?
The FOA description notes examples such as improved modeling, data harmonization, bias adjustment, missing data strategies, and validation approaches tailored to vision datasets.
What are examples of substantive research questions that could fit?
Examples mentioned include studies of risk factors, disease progression, disparities, outcomes, and real-world patterns of care, provided they are addressed through analysis of existing data resources.
What is the funding activity area for this opportunity?
The opportunity is categorized as a grant in the health funding activity area.
What is the listed award ceiling?
The announcement record lists an award ceiling of $275,000.
When was this opportunity created?
The opportunity was created on March 15, 2022.
What is the closing date shown for this opportunity?
The original closing date shown is May 7, 2025.
Who is eligible to apply (general categories)?
Eligible applicants include many organization types, such as state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (excluding higher education institutions, which are listed separately); for-profit organizations other than small businesses; small businesses; and other eligible organizations.
Does the FOA encourage applications from specific institution types?
Yes. The FOA explicitly welcomes applications from a wide set of additional applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly welcomes applications from U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA explicitly welcomes non-U.S. entities (foreign organizations).
Are federal agencies eligible to apply?
Yes. The FOA explicitly welcomes eligible federal agencies.
What should applicants emphasize in their proposals based on the FOA description?
Applicants should plan feasible, well-justified analyses appropriate for an R21-style scope, clearly identify the existing data source(s) they will use, explain the analytic plan and statistical rigor, and show how the project will advance vision research without initiating a clinical trial.
Do projects need to identify the specific dataset(s) they will analyze?
Yes. The FOA description indicates proposals should clearly identify the existing data source(s) to be used.
Can an application propose collecting new primary data?
The FOA is described as supporting studies that rely on analyzing data that already exist rather than collecting new primary data through a clinical trial. Proposed work should be structured around secondary analyses of established datasets or databases and should not involve a clinical trial.
Why does this FOA have broad eligibility across many organization types?
As described, the broad eligibility is intended to encourage participation from diverse institutional types and communities, including organizations that may bring unique datasets, expertise, or perspectives on vision health and disparities.
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