Opportunity Information: Apply for PAR 24 129
The NIH funding opportunity PAR-24-129, titled "Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)," is a discretionary health-related cooperative agreement designed to continue supporting a small set of already-established macaque breeding colonies that serve HIV/AIDS research needs. The core goal is continuity: this NOFO specifically targets colonies that were previously funded under PAR-21-089 and PAR-18-669, recognizing that maintaining high-quality, research-ready nonhuman primate resources is a long-term infrastructure commitment rather than a short, one-off project. By keeping these colonies stable and productive, the program helps ensure a reliable supply of animals that are appropriate for studies of HIV and related viruses, including simian immunodeficiency virus (SIV), which is widely used in nonhuman primate models of AIDS.
A central focus of the program is the maintenance of "specific pathogen-free" (SPF) macaques with documented pedigrees. In this context, SPF means the animals are free of particular viruses that could otherwise complicate research outcomes or introduce safety concerns for animal care and research personnel. Those background infections can change immune function, alter disease progression, or interfere with interpreting experimental readouts, which is especially problematic in HIV/AIDS research where immune responses and virologic measures are central endpoints. The NOFO emphasizes that breeding colonies are essential infrastructure because they are the mechanism by which an ongoing, predictable pipeline of these appropriately screened animals is produced and sustained over time.
Beyond pathogen status, the NOFO highlights genetic characterization, specifically major histocompatibility complex (MHC) class I typing. This matters because MHC class I genotypes can strongly influence how macaques respond immunologically to SIV infection and SIV-based challenge studies, which in turn affects key research outcomes relevant to HIV vaccine development, cure strategies, immunotherapies, and pathogenesis. By maintaining colonies where animals are both SPF and genetically characterized for MHC class I, the program supports better-controlled experiments and improves the ability of researchers to compare results across studies, cohorts, and time. In practical terms, having animals with known MHC class I backgrounds can reduce variability, support better study design (for example, balancing genotype distributions across study arms), and help interpret immune correlates of protection or disease progression.
This is a cooperative agreement (U42), meaning NIH anticipates substantial programmatic involvement compared with a standard research project grant. The opportunity is also explicitly "Clinical Trial Not Allowed," reflecting that the award supports a resource and infrastructure function (the establishment and maintenance of colonies and associated characterization) rather than clinical intervention studies. The NOFO is labeled a limited competition, which aligns with its stated purpose of continuing support for specific colonies previously funded under the earlier announcements rather than opening a broad, fully open competition to all potential applicants.
Eligibility is restricted. The source information indicates eligible applicants include public and state-controlled institutions of higher education, and the NOFO text makes clear that foreign organizations are not eligible to apply. It also excludes non-domestic components of U.S. organizations and does not allow foreign components as defined by the NIH Grants Policy Statement. In other words, this program is intended to be administered and carried out entirely within eligible U.S.-based institutional structures, and applicants should pay close attention to the specific eligibility language in the NOFO to confirm they fit the limited, continuation-oriented scope.
Administrative details provided include that the sponsoring agency is the National Institutes of Health, the opportunity falls under CFDA numbers 93.310 and 93.351, and the original closing date listed is 2027-01-07. The NOFO was created on 2024-01-22. An award ceiling and expected number of awards are not specified in the provided source fields, which often means applicants must consult the full NOFO text for budget parameters, anticipated award counts, and any institute-specific funding expectations.
Overall, this funding opportunity is best understood as NIH support for specialized national research infrastructure: maintaining well-controlled, pedigree SPF macaque colonies with relevant genetic typing so HIV/AIDS investigators can access animals that are both safer to work with and scientifically appropriate for immune-focused SIV/HIV modeling. The emphasis on continuity from prior awards, strict eligibility limits, and the cooperative agreement mechanism all reinforce that NIH is sustaining a critical, curated resource rather than funding unrelated new colony efforts or broad exploratory research projects.Apply for PAR 24 129
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310, 93.351.
- This funding opportunity was created on 2024-01-22.
- Applicants must submit their applications by 2027-01-07.
- Eligible applicants include: Public and State controlled institutions of higher education.
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